Trends in β‐Lactam Resistance Among Enterobacteriaceae

Emerging Carbapenem Resistance in Enterobacteriaceae

Objective: To determine the frequency of carbapenem resistance in Enteriobacteriaceae. Study design: Cross-sectional study. Setting: Study was carried out from January 2011 to December 2011, in the Department of Microbiology, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), where 500 samples were collected from patients admitted in wards and ICUs of JPMC. Meth...

Resistance plasmid families in Enterobacteriaceae.

Bacteria carry extrachromosomal, self-replicating genetic elements called plasmids. A plasmid is defined as a doublestranded, circular DNA molecule capable of autonomous replication. By definition, plasmids do not carry genes essential for the growth of host cells under nonstressed conditions (109). Plasmids have systems which guarantee their autonomous replication but also have mechanisms cont...

Antibiotic resistance mechanisms in Enterobacteriaceae

Enterobacteriaceae species are important human pathogens while increasing number of antibiotic resistant strains are detected worldwide. The most common antibiotic resistance in Enterobacteriaceae is observed against beta-lactams, fluoroquinolones, aminoglycosides while recently resistance to polymyxins has also appeared. Beta-lactam resistance is mainly conferred by beta-lactamases, capable to...

Trends in Fluoroquinolone (Ciprofloxacin) Resistance in Enterobacteriaceae from Bacteremias, England and Wales, 1990–1999

The Public Health Laboratory Service receives antibiotic susceptibility data for bacteria from bloodstream infections from most hospitals in England and Wales. These data were used to ascertain resistance trends to ciprofloxacin from 1990 through 1999 for the most prevalent gram-negative agents: Escherichia coli, Klebsiella spp., Enterobacter spp., and Proteus mirabilis. Significant increases i...

trends in antimicrobial resistance